ea0026p363 | Adrenal medulla | ECE2011
De Martino M C
, Feelders R A
, van Koetsveld P M
, De Krijger R R
, Janssen J A M J L
, Sprij-Mooij D
, Lamberts S W J
, de Herder W W
, Colao Annamaria
, Pivonello Rosario
, Hofland Leo
The pathogenesis of pheochromocytomas (pheo) is poorly understood and malignant pheo need new treatment options. mTOR inhibitors, as sirolimus (S) and everolimus (E), are new promising antineoplastic drugs.Aim: To evaluate whether the IGF/mTOR pathways have a role in the pathogenesis and whether S and E may have antiproliferative effects in pheo.In 24 human pheo and two normal adrenal medulla (NM), we evaluated the mRNA expression ...